Project title: Bioconjugated Magnetic Nanoparticles Designed for Multimodal Cancer Therapy
Project manager: Dr Marija Mirković, Research associate
Budžet Projekta: 20.000 EUR
The project is focused on development of multifunctional nanoparticles for malignant tumor therapy, based on combining of magnetic nanoparticles’ (MNPs) heating ability in alternating magnetic field, radioactivity derived from radiolabeling and/or chemotherapeutic induced cytotoxicity. The focus has been put on additive effect of local magnetic hyperthermia to the local radionuclide therapy and/or chemotherapy as a very attractive therapeutic strategy. Synthesis and characterization of improved multifunctional nanoparticles for magnetic hyperthermia application created by German group, will be further radiolabeled in high yields and biologically tested in detail by complex investigation of interaction of nanoparticles with biological system (cell and tissue) by Serbian group. In order to have an in vitro and in vivo stable multifunctional system for magnetic radiohyperthermia application, magnetic nanoparticles are synthesized, functionalized, and labeled with 90Y, 177Lu, and 131I. In vitro tests on different cancer cell lines should give answer on cell termosensitivity and understanding mechanisms of interaction of cell-multifunctional system with magnetic nanoparticles (MNPs) as its core. Finally, in vivo test on a tumor bearing mice should give answer concerning the effect of hyperthermia, chemo and radionuclide therapy and their synergistic effects.