{"id":997,"date":"2019-02-06T10:04:31","date_gmt":"2019-02-06T09:04:31","guid":{"rendered":"http:\/\/www.vincent.org.rs\/en\/?page_id=997"},"modified":"2019-02-06T10:37:17","modified_gmt":"2019-02-06T09:37:17","slug":"long-term-fate-of-iron-oxide-nanoparticles-in-the-body-a-long-and-comprehensive-survey","status":"publish","type":"page","link":"http:\/\/www.vincent.org.rs\/en\/f_gazeau_abstract\/","title":{"rendered":"Long term fate of iron oxide nanoparticles in the body: a long and comprehensive survey"},"content":{"rendered":"\n<p><strong><a href=\"http:\/\/www.vincent.org.rs\/en\/f_gazeau\/\">Florence Gazeau<\/a><\/strong><\/p>\n\n\n\n<p><em>MSC Universit\u00e9 Paris Diderot\/CNRS, USPC, Paris, France<\/em><\/p>\n\n\n\n<p>Iron oxide nanoparticles\n(IONPs) are among the most promising nanomaterials in biomedicine mostly due to\ntheir unique magnetic properties but also to their biocompatibility and\ndegradability. However, some questions remain on their long-term fate and\nbiotransformation in the organism. How long will the nanoparticles keep their\nmagnetic properties and be useful for applications? Where does the degradation\ntake place? What are the mechanisms? What is the fate of degradation products?\nIs there any recycling&nbsp;and transfer between organs? What is the journey of\nthe different particle components, the core and the shell? Which biological response\/adaptation\nto IONP overload and degradation?<\/p>\n\n\n\n<p>I will present some of our\nlatest results regarding the fate of different types of IONP in mice.\n\nA part of my talk will focus on a possible\npathway for metabolizing IONP degradation products through a protein involved\nin iron metabolism, the ferritin. We have studied, in solution, the degradation\nprocesses of iron oxide nanoparticles in the presence of ferritin proteins as\nwell as the iron transfer processes from nanoparticles to ferritin. The\ndifficulty is the high concentration of endogenous iron which makes it\nimpossible to demonstrate such transfers <em>in\nvivo<\/em>. Thus, we have developed a strategy to track these phenomena <em>in vivo<\/em> by doping iron oxide\nnanoparticles with a scarce element in the organism, such as cobalt. This work\nhighlighted a possible mechanism of biological recycling, remediation\nand detoxification of metal oxide nanoparticles mediated by endogenous proteins\nat the molecular scale. We also developed a multi-scale method to study the\nlife cycle of iron oxide nanoparticles and their by-products in the organism.\nThe main challenge is to differentiate iron steming from the nanoparticles from\nendogeneous iron. This specific tracking problem is routinely encountered in\ngeochemical studies and solved by labelling the target material with minor\nstable isotopes. Therefore, iron oxide nanoparticles enriched in the minor\nstable isotope <sup>57<\/sup>Fe were synthetised and injected intravenously in\nmice to follow dynamic circulations of iron oxide nanoparticles and their\nby-products over a period of six months. We have also labelled the particle\ncoating to track the integrity of nanoparticles over time and decipher the\nspecific fates of inorganic core and organic shell. Results of this\ncomprehensive in vivo study will be discussed together with modifications of\ngene expression related to the presence, accumulation and degradation of IONPs\nat different doses and in different organs. Comparison with different types of\nmaterials, e.g. gold nanoparticles, will be highlighted.\n\n\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Florence Gazeau MSC Universit\u00e9 Paris Diderot\/CNRS, USPC, Paris, France Iron oxide nanoparticles (IONPs) are among the most promising nanomaterials in biomedicine mostly due to their unique magnetic properties but also to their biocompatibility and degradability. However, some questions remain on their long-term fate and biotransformation in the organism. How long will the nanoparticles keep their [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/997"}],"collection":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/comments?post=997"}],"version-history":[{"count":2,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/997\/revisions"}],"predecessor-version":[{"id":1021,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/997\/revisions\/1021"}],"wp:attachment":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/media?parent=997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}