{"id":984,"date":"2019-02-05T15:00:23","date_gmt":"2019-02-05T14:00:23","guid":{"rendered":"http:\/\/www.vincent.org.rs\/en\/?page_id=984"},"modified":"2019-03-14T09:03:34","modified_gmt":"2019-03-14T08:03:34","slug":"thermal-therapies-mediated-by-iron-oxide-based-nanoparticles-quantitative-comparison-of-heat-generation-therapeutic-efficiency-and-limitations","status":"publish","type":"page","link":"http:\/\/www.vincent.org.rs\/en\/a_espinosa_abstract\/","title":{"rendered":"Thermal therapies mediated by iron oxide-based nanoparticles: quantitative comparison of heat generation, therapeutic efficiency and limitations"},"content":{"rendered":"\n<p><strong><a href=\"http:\/\/www.vincent.org.rs\/en\/a_espinosa\/\">Ana Espinosa<\/a><\/strong><sup>1,2,3<\/sup><\/p>\n\n\n\n<p><em><sup>I<\/sup><\/em><em> MDEA Nanociencia,\nc\/Faraday, 9, 28049 Madrid, Spain<\/em><\/p>\n\n\n\n<p><em><sup>2<\/sup> Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes, UMR 7057, CNRS<\/em> and<br \/><em> University Paris Diderot, 75205 Paris cedex 13, France<\/em> <\/p>\n\n\n\n<p><em><sup>3<\/sup> Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Cient\u00edficas, Cantoblanco, E-28049 Madrid, Spain<\/em><\/p>\n\n\n\n<p>Thermal\nnanotherapies as magnetic hyperthermia (MHT) and photothermal therapy (PTT) are\ntwo promising emergent treatments and non<em>&#8211;<\/em>invasive\napproaches for tumor ablation, where localized heat generation is mediated by\nmagnetic and photo-activatable nanomaterials<a href=\"#_ftn1\">[1]<\/a><a href=\"#_ftn2\">[2]<\/a>.\nUntil very recently, these thermal nanotherapies, have been developed\nseparately: MHT is mainly focused on the use of magnetic iron oxide\nnanoparticles due to their excellent biodegradability<a href=\"#_ftn3\">[3]<\/a>,\nwhile metallic nanoparticles such as gold nanomaterials are often preferred due\nto their strong absorption cross sections. They have recently begun to\nintersect due to the recent discovery and use of photothermal properties of\niron oxide nanostructures<a href=\"#_ftn4\">[4]<\/a>\nor to the use of magneto-photothermal hybrids<a href=\"#_ftn5\">[5]<\/a>,\nwhich efficiently combine both heating features in one-single object.<\/p>\n\n\n\n<p>A\ncomprehensive comparison of the heating efficiency of magneto- versus\nphoto-thermal effect is presented, where different magnetic nanoparticles have\nbeen confronted (iron oxides, cobalt ferrite, spheres, cubes, flowers) with\ndifferent metallic nanoparticles in aqueous, cellular, and tumoral environment<a href=\"#_ftn6\">[6]<\/a>.\nIntracellular processing markedly impacted MHT, while endosomal sequestration\ncould have a positive effect for PTT. In the search for the most\ntherapeutically viable modality, the effect of nanoparticle concentration and\nthe experimental exposure parameters (magnetic field strengths\/frequencies and\nlaser power densities) have been investigated. The intracellular\nbiotransformations of these nanomaterials in the biological environment has\nalso been explored through the study of their physical and chemical\nmodifications at the nanoscale over the time<a href=\"#_ftn7\">[7]<\/a>.<\/p>\n\n\n\n<p>Aknowledgements: MINECO project SEV-2016-0686, Comunidad de Madrid 2018-T1\/IND-1005 and P2018\/NMT-4321NANOMAGCOST .<br \/><\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"#_ftnref1\">[1]<\/a> R.\nHergt and S. Dutz, J. Magn. Magn. Mater. <strong>311<\/strong>,\n187 (2007).<\/p>\n\n\n\n<p><a href=\"#_ftnref2\">[2]<\/a> M. Garcia, Journal of Physics D: Applied Physics <strong>44<\/strong>, 283001 (2011).<strong><\/strong><\/p>\n\n\n\n<p><a href=\"#_ftnref3\">[3]<\/a> A.\nG. Roca, L. Guti\u00e9rrez, H. Gavil\u00e1n, M. E. F. Brollo, S. Veintemillas-Verdaguer,\nand M. del Puerto Morales, Adv. Drug Deliv. Rev. (2018).<\/p>\n\n\n\n<p><a href=\"#_ftnref4\">[4]<\/a> A.\nEspinosa, R. Di Corato, J. Kolosnjaj-Tabi, P. Flaud, T. Pellegrino, and C.\nWilhelm, ACS Nano <strong>10<\/strong>, 2436 (2016).<\/p>\n\n\n\n<p><a href=\"#_ftnref5\">[5]<\/a> A.\nEspinosa, M. Bugnet, G. Radtke, S. Neveu, G. A. Botton, C. Wilhelm, and A.\nAbou-Hassan, Nanoscale <strong>7<\/strong>, 18872\n(2015).<\/p>\n\n\n\n<p><a href=\"#_ftnref6\">[6]<\/a> A.\nEspinosa <em>et al.<\/em>, Adv. Funct. Mater. <strong>28<\/strong>, 1803660 (2018).<\/p>\n\n\n\n<p><a href=\"#_ftnref7\">[7]<\/a> F.\nMazuel, A. Espinosa, G. Radtke, M.\nBugnet, S. Neveu, Y. Lalatonne, G. A. Botton, A. Abou\u2010Hassan, and C. Wilhelm, Adv. Funct. Mater. <strong>27<\/strong>, 1605997 (2017).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ana Espinosa1,2,3 I MDEA Nanociencia, c\/Faraday, 9, 28049 Madrid, Spain 2 Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes, UMR 7057, CNRS and University Paris Diderot, 75205 Paris cedex 13, France 3 Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Cient\u00edficas, Cantoblanco, E-28049 Madrid, Spain Thermal nanotherapies as magnetic hyperthermia (MHT) and photothermal therapy (PTT) [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/984"}],"collection":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/comments?post=984"}],"version-history":[{"count":4,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/984\/revisions"}],"predecessor-version":[{"id":1185,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/984\/revisions\/1185"}],"wp:attachment":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/media?parent=984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}