{"id":982,"date":"2019-02-05T14:59:16","date_gmt":"2019-02-05T13:59:16","guid":{"rendered":"http:\/\/www.vincent.org.rs\/en\/?page_id=982"},"modified":"2019-02-06T10:34:58","modified_gmt":"2019-02-06T09:34:58","slug":"nanomagnetic-approaches-for-vascular-healing-and-cardiac-regeneration","status":"publish","type":"page","link":"http:\/\/www.vincent.org.rs\/en\/b_polyak_abstract\/","title":{"rendered":"Nanomagnetic approaches for vascular healing and cardiac regeneration"},"content":{"rendered":"\n<p><strong><a href=\"http:\/\/www.vincent.org.rs\/en\/b_polyak\/\">Boris Polyak<\/a><\/strong><\/p>\n\n\n\n<p><em>Department of Surgery, Drexel University College of Medicine, Philadelphia, USA<\/em><\/p>\n\n\n\n<p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nMagnetic nanoparticles and various magnet\nsystems have been used in a range of\napplications aimed to achieve localized delivery of therapy and tissue\nregeneration. For local delivery of therapy, magnetic carriers associated with\ndrugs, nucleic acids or loaded within cells are directed or guided by magnetic forces towards certain biological\ntargets. The magnetic delivery of therapeutic agents results in the\nconcentration of the therapy at the target site, consequently improving therapy\ndelivery efficiency while reducing or eliminating the systemic therapy side\neffects. For tissue regeneration, magnetic nanomaterials are used in remotely\ncontrolled actuation for the release of\nbioactive molecules or mechanical conditioning of cells to generate tissue\nconstructs for restorative tissue support or reconstruction. Mechanical\nconditioning of cells and tissue constructs is an important factor in\ndetermining the properties of the tissue being produced. This conditioning is\nparticularly relevant to the generation\nof vascularized cardiac muscle, where mechanical stress activates\nmechano-sensitive receptors, triggering\nbiochemical pathways that promote the\nproduction of functional tissue. This talk will present two applications where\nthe magnetic approach has the potential\nto enable tissue restoration or support. One example will present an innovative\nmethod that takes advantage of magnetic nanoparticles and intravascular steel\nstents to deliver endothelial cells to the blood vessels with the ultimate aim\nto repair the injured artery. Another study will present a novel strategy for\ncreating a vascularised and functional tissue graft by combining the use of a\nmacroporous alginate scaffold impregnated with magnetically responsive\nnanoparticles in combination with non-invasive magneto-mechanical stimulation.\nWhile a distinct mechanism underlines the\nstrategies described in each example, both cases demonstrate versatile\ncapabilities of magnetic systems for regenerative applications.\n\n\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Boris Polyak Department of Surgery, Drexel University College of Medicine, Philadelphia, USA Magnetic nanoparticles and various magnet systems have been used in a range of applications aimed to achieve localized delivery of therapy and tissue regeneration. For local delivery of therapy, magnetic carriers associated with drugs, nucleic acids or loaded within cells are directed or [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/982"}],"collection":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/comments?post=982"}],"version-history":[{"count":4,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/982\/revisions"}],"predecessor-version":[{"id":1017,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/982\/revisions\/1017"}],"wp:attachment":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/media?parent=982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}