{"id":1083,"date":"2019-02-20T07:47:15","date_gmt":"2019-02-20T06:47:15","guid":{"rendered":"http:\/\/www.vincent.org.rs\/en\/?page_id=1083"},"modified":"2019-02-20T07:47:16","modified_gmt":"2019-02-20T06:47:16","slug":"functional-carbon-nanohybrid-for-improved-vectorization-of-anticancer-therapeutics","status":"publish","type":"page","link":"http:\/\/www.vincent.org.rs\/en\/g_cirillo_abstract\/","title":{"rendered":"Functional carbon nanohybrid for improved vectorization of anticancer therapeutics"},"content":{"rendered":"\n

Giuseppe Cirillo<\/a><\/strong><\/p>\n\n\n\n

Department of Pharmacy, Health and Nutritional Sciences – University of Calabria \u2013 87036 \u2013 Rende (CS) \u2013 Italy. Tel\/Fax 0039 0984493011<\/em><\/p>\n\n\n\n

Carbon nanostructures, consisting of hexagonal sp2<\/sup>-bonded\ncarbon atoms lattices possessed superior electrical, chemical, physical,\nmechanical, and biological properties \nmaking them some of the most attracting materials for\nthe fabrication of highly engineered drug delivery carriers, mainly in the form\nof nanohybrids 1, 2<\/sup>. Such\nmaterials, resulting from the combination of carbon nanostructures (mainly\nCarbon Nanotubes \u2013 CNT, and Nanographene Oxide \u2013 NGO) with different types of\npolymers from both synthetic and natural origin, are receiving increasing\nattention for application in biomedicine 3<\/sup>.\nIn addition, we recently proved that the functionalization of the polymer\ncounterpart with biologically active molecules (e.g. polyphenol compounds) is a\nvaluable strategy to obtain of a functional drug delivery system, in which the\nbiological effect are related to both the loaded drug and the carrier itself 4-6<\/sup>. A further improvement can be\nachieved by the insertion of magnetic nanoparticles, with the obtainment of\ndelivery vehicles able to localize the delivery of payload at the proper site 7<\/sup>. <\/p>\n\n\n\n

Here,\nthe most recent insights and promising strategies to design magnetic carbon\nnanohybrid-based therapeutics for biomedical applications are presented by a\nmultidisciplinary approach, which combines expertise in biology, chemistry,\nradiobiology and oncology.<\/p>\n\n\n\n

1.             Mohajeri, M.;  Behnam, B.; Sahebkar, A., Biomedical\napplications of carbon nanomaterials: Drug and gene delivery potentials. J Cell Physiol <\/em>2018<\/strong>.<\/p>\n\n\n\n

2.             Biagiotti, G.;  Fedeli, S.; \nTuci, G.;  Luconi, L.;  Giambastiani, G.;  Brandi, A.; \nPisaneschi, F.;  Cicchi, S.;\nPaoli, P., Combined therapies with nanostructured carbon materials: There is\nroom still available at the bottom. Journal\nof Materials Chemistry B <\/em>2018,<\/strong> 6<\/em> (14), 2022-2035.<\/p>\n\n\n\n

3.             Vedhanarayanan, B.;  Praveen, V. K.;  Das, G.; Ajayaghosh, A., Hybrid materials of\n1D and 2D carbon allotropes and synthetic \u03c0-systems. NPG Asia Materials <\/em>2018,<\/strong>\n10<\/em> (4), 107-126.<\/p>\n\n\n\n

4.             Vittorio, O.;  Brandl, M.; \nCirillo, G.;  Kimpton, K.;  Hinde, E.; \nGaus, K.;  Yee, E.;  Kumar, N.; \nDuong, H.;  Fleming, C.;  Haber, M.; \nNorris, M.;  Boyer, C.;\nKavallaris, M., Dextran-Catechin: An anticancer chemically-modified natural\ncompound targeting copper that attenuates neuroblastoma growth. Oncotarget <\/em>2016,<\/strong> 7<\/em> (30),\n47479-47493.<\/p>\n\n\n\n

5.             Vittorio, O.;  Brandl, M.; \nCirillo, G.;  Spizzirri, U.\nG.;  Picci, N.;  Kavallaris, M.;  Iemma, F.; Hampel, S., Novel functional\ncisplatin carrier based on carbon nanotubes-quercetin nanohybrid induces\nsynergistic anticancer activity against neuroblastoma in vitro. RSC Advances <\/em>2014,<\/strong> 4<\/em> (59),\n31378-31384.<\/p>\n\n\n\n

6.             Kunz-Schughart, L. A.;  Dubrovska, A.;  Peitzsch, C.; \nEwe, A.;  Aigner, A.;  Schellenburg, S.;  Muders, M. H.;  Hampel, S.; \nCirillo, G.;  Iemma, F.;  Tietze, R.; \nAlexiou, C.;  Stephan, H.;  Zarschler, K.;  Vittorio, O.; \nKavallaris, M.;  Parak, W.\nJ.;  M\u00e4dler, L.; Pokhrel, S.,\nNanoparticles for radiooncology: Mission, vision, challenges. Biomaterials <\/em>2017,<\/strong> 120<\/em>, 155-184.\n\n7.             Lerra,\nL.;  Farfalla, A.;  Sanz, B.; \nCirillo, G.;  Vittorio, O.;  Voli, F.; \nGrand, M. L.;  Curcio, M.;  Nicoletta, F. P.;  Dubrovska, A.;  Hampel, S.; \nIemma, F.; Goya, G. F., Graphene oxide functional nanohybrids with\nmagnetic nanoparticles for improved vectorization of doxorubicin to\nneuroblastoma cells. Pharmaceutics <\/em>2019,<\/strong>11<\/em> (1).\n\n\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"

Giuseppe Cirillo Department of Pharmacy, Health and Nutritional Sciences – University of Calabria \u2013 87036 \u2013 Rende (CS) \u2013 Italy. Tel\/Fax 0039 0984493011 Carbon nanostructures, consisting of hexagonal sp2-bonded carbon atoms lattices possessed superior electrical, chemical, physical, mechanical, and biological properties  making them some of the most attracting materials for the fabrication of highly engineered […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/1083"}],"collection":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/comments?post=1083"}],"version-history":[{"count":1,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/1083\/revisions"}],"predecessor-version":[{"id":1084,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/1083\/revisions\/1084"}],"wp:attachment":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/media?parent=1083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}