{"id":1073,"date":"2019-02-20T07:36:30","date_gmt":"2019-02-20T06:36:30","guid":{"rendered":"http:\/\/www.vincent.org.rs\/en\/?page_id=1073"},"modified":"2019-03-14T12:38:45","modified_gmt":"2019-03-14T11:38:45","slug":"magnetic-nanoparticles-for-dual-anti-cancer-therapies-to-synergize-hyperthermia-mandath-synh","status":"publish","type":"page","link":"http:\/\/www.vincent.org.rs\/en\/z_prijovic_abstract\/","title":{"rendered":"Magnetic nanomaterial as a mediator, carrier and trigger for hyperthermia-complementing combined therapies of tumors: MagBioVin approach"},"content":{"rendered":"\n<p><strong><a href=\"http:\/\/www.vincent.org.rs\/en\/z_prijovic\/\">\u017deljko Prijovi\u0107<\/a><\/strong><\/p>\n\n\n\n<p><em>Vin\u010da institute of nuclear sciences, University of Belgrade, Belgrade, Serbia<\/em><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Effective\nheating of the super-paramagnetic nanoparticles (MNPs) by alternating magnetic\nfield (AMF) serves as a base for development of AMF-generated hyperthermia for\ntumor therapy. Despite being thoroughly investigated by years and the basic\nidea confirmed <em>in vitro<\/em>, it is\nsparsely used in clinics. The limitations arising from basic laws of physics,\nnature of the material and interaction with biological systems hamper the\napplicability <em>in vivo<\/em>. Namely,\nresembling some properties of viruses and bacteria, most of the MNPs encounter\nbiological barriers and immune system components when applied <em>in vivo<\/em>, leaving relatively small\namounts of MNPs capable of reaching the tumor. An opposite process, enhanced\npermeability and retention (EPR), allows MNPs to reach the tumor and retain\nthere. However, it is frequently not sufficient to accumulate enough MNPs to\neffectively heat large volume of the tumor, hampering the use of therapy. Also,\nnature of MNP-mediated hyperthermia limits the cells damage to short distance\nonly. <\/p>\n\n\n\n<p>Combining\nour expertise in magnetism, radioisotopes, pharmacology and cancer biology in\nproject MagBioVin, we focused on improving all phases of the approach, aiming\nto generate material and therapeutic approaches suitable for <em>in vivo<\/em> application. Aiming that goal,\nwe have been optimizing the preparation of MNPs and their coating by various\ncompounds (citrate, PEG, DOTA, dopamine, lysine etc\u2026) to improves their\ncirculation half-life, help avoiding immune system, lower the toxicity and\nserve as a linker for radioisotopes, drugs and bio-macromolecules. The produced\nmaterial is screened for cytotoxicity and hyperthermia-induced cell death on\nmouse and human cancer cell lines <em>in\nvitro<\/em>. Material with suitable characteristic serves as a base for <em>in vivo<\/em> application. <\/p>\n\n\n\n<p>Potential\nfor tumor therapy of coated and derivatized MNPs have been tested <em>in vitro<\/em> measuring its impact on cancer\ncells in tissue culture and <em>in vivo<\/em>\non the impact on growth of mouse and human tumor xenografts on immune-competent\nand immune compromised mice. The data confirmed the basic mode of action but\nfacing the same limitations as reported earlier. To overcome them, we have been\nfocused on developing combined therapies, by linking the MNPs to agents\ncomplementing or synergizing hyperthermia, as radionuclides (<sup>131<\/sup>I, <sup>90<\/sup>Y,\n<sup>177<\/sup>Lu, <sup>99m<\/sup>Tc\u2026), anticancer drugs (camptothecins), signal\nmolecules (IL12), antibodies (CC49\/Tag72) and enzymes (beta-Glucuronidase). The\nmechanism of action of the obtain material may have better pharmacological and\ntherapeutic effects, surpassing hyperthermia alone, justifying their further\ndevelopment for eventual therapeutic approach.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u017deljko Prijovi\u0107 Vin\u010da institute of nuclear sciences, University of Belgrade, Belgrade, Serbia Effective heating of the super-paramagnetic nanoparticles (MNPs) by alternating magnetic field (AMF) serves as a base for development of AMF-generated hyperthermia for tumor therapy. Despite being thoroughly investigated by years and the basic idea confirmed in vitro, it is sparsely used in clinics. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/1073"}],"collection":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/comments?post=1073"}],"version-history":[{"count":3,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/1073\/revisions"}],"predecessor-version":[{"id":1193,"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/pages\/1073\/revisions\/1193"}],"wp:attachment":[{"href":"http:\/\/www.vincent.org.rs\/en\/wp-json\/wp\/v2\/media?parent=1073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}