Magnetic nanocomposites for biomedical applications. Participants: VINCENT (Serbia, Dr Jovan Blanusa) and Slovakia (Dr. Maria Zentkova
The proposed research concerns magnetic nanocomposites consisting of nanosized ferrimagnetic particles (iron-oxides, spinel ferrites and manganites) embedded in/coated with silica or certain polymers. These nanomaterials have been intensively studied in the recent years due to their importance from the viewpoint of both basic research and possible applications, especially in biomedicine. Besides having adjustable magnetic properties such materials are convenient for biomedical applications due to nontoxicity (biocompatibility) and ability to be further functionalized by attaching ligands appropriate for targeted application (magnetic separation of cells and biomolecules, drug delivery, tissue engineering, etc.).
In the focus of this project will be research on the nanocomposites for applications that favor superaramagnetic nanoparticles, i.e. those magnetic nanoparticles (MNPs) that possess high magnetic moment but exhibits magnetism only in the presence of magnetic field. Such requirement is present in biomedical applications where precise positioning of MNPs in the tissue/organ by external magnetic field is required (drug delivery, tissue engineering), as well as in magnetic bioseparation. The preferable nanoparticle size is in the range 10-100 nm which favours the uptake of nanoparticles by cells while minimising the filtering in the spleen. Another advantageous property is size uniformity (i.e. narrow size distribution) that enables uniform behaviour of magnetic nanoparticles under the applied magnetic field.